Can bailiffs take a locked safe, unaware of the contents inside?

Yes

The same applies to taking a locked vehicle or van without knowing what is inside.

If the goods contain further goods, and the enforcement agent has not inventoried them, then he is liable for their replacement cost if they go missing.^[1][2][3][4]

The owner of the inventoried goods may apply to the court for an injunction to recover them.^[5]

If the goods are a locked safe, then the bailiff is liable for damage to the goods if he breaks open or tries to break open the safe.^[5][6][7]

In reality, when entering a middle-class home, and nobody is in, they prefer to steal jewellery. They know the police will consider the crime to be a civil matter and refuse to investigate or search the suspect and his vehicle.^[8]

If the premises is a shop, the bailiff will pocket the cash taken from the till, even if there is a camera directly above the till.^[9]

^{[1] Paragraph 34 of Schedule 12 of the Tribunals Courts and Enforcement Act 2007.
[2] Regulation 33 of the Taking Control of Goods Regulations 2013.
[3] Paragraph 66 of Schedule 12 of the Tribunals Courts and Enforcement Act 2007.
[4] Section 3 of the Torts (Interference with Goods) Act 1977
[5] Section 4 the Torts (Interference with Goods) Act 1977
[6] Paragraph 35 of Schedule 12 of the Tribunals Courts and Enforcement Act 2007.
[7] Regulation 34 of the Taking Control of Goods Regulations 2013.
[8] Virgil Munteanu as enforcement agent, at Westergate Road, London, SE2 0DR. 12 August 2021
[9] Virgil Munteanu as enforcement agent, at NuvoGel Nail Bar, Ascot Parade, Clapham Park Road, London SW4 7EY. 6 October 2021}